| 163 | "Discovery of novel µ-opioid receptor inverse agonist from a combinatorial library of tetrapeptides through structure-based virtual screening." Poli G, Dimmito MP, Mollica A, Zengin G, Benyhe S, Zador F, Stefanucci A. Molecules. 2019,24(21). pii: E3872. Link to Journal |
| 162 | "Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-Spyrazoles." Guglielmi P, Carradori S, Poli G, Secci D, Cirilli R, Rotondi G, Chimenti P, Petzer A, Petzer JP. Molecules. 2019,24(3). pii: E484. Link to Journal  |
| 161 | "Rutin as promising drug for the treatment of Parkinson’s disease: an assessment of MAO-B inhibitory potential by docking, molecular dynamics and DFT studies." Azam F, Abodabos HS, Taban IM, Rfieda AR, Mahmood D, Anwar MJ, Khan S, Sizochenko N, Poli G, Tuccinardi T, Ali HI. Mol SImul 2019,45:1563-1571. Link to Journal |
| 160 | "The influence of Echinacea purpurea leaf microbiota on chicoric acid level." Maggini V, De Leo M, Granchi C, Tuccinardi T, Mengoni A, Gallo ER, Biffi S, Fani R, Pistelli L, Firenzuoli F, Bogani 6. Sci Rep. 2019,9(1):10897. Link to Journal |
| 159 | "Identification of the First Synthetic Allosteric Modulator of the CB 2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief." Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C. J Med Chem. 2019,62(1):276-287. Link to Journal  |
| 158 | "Stereoselectivity of aldose reductase in the reduction of glutathionyl-hydroxynonanal adduct." Balestri F, Barracco V, Renzone G, Tuccinardi T, Pomelli CS, Cappiello M, Lessi M, Rotondo R, Bellina F, Scaloni A, Mura U, Del Corso A, Moschini R. Antioxidants (Basel). 2019,8(10). pii: 502. Link to Journal  |
| 157 | "Synthesis and biological evaluation of new glycoconjugated LDH inhibitors as anticancer agents." D'Andrea F, Vagelli G, Granchi C, Guazzelli L, Tuccinardi T, Poli G, Iacopini D, Minutolo F, Di Bussolo V. Molecules. 2019,24(19). pii: E3520. Link to Journal  |
| 156 | "Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects." Russo Spena C, De Stefano L, Poli G, Granchi C, El Boustani M, Ecca F, Grassi G, Grassi M, Canzonieri V, Giordano A, Tuccinardi T, Caligiuri I, Rizzolio F. J Cell Physiol. 2019 [Epub ahead of print] Link to Journal |
| 155 | "Former foodstuff products in Tenebrio molitor rearing: Effects on growth, chemical composition, microbiological load, and antioxidant status." Mancini S, Fratini F, Turchi B, Mattioli S, Dal Bosco A, Tuccinardi T, Nozic S, Paci G. Animals (Basel). 2019,9(8).pii: E484. Link to Journal  |
| 154 | "N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties." Bozdag M, Poli G, Angeli A, Lucarini E, Tuccinardi T, Di Cesare Mannelli L, Selleri S, Ghelardini C, Winum JY, Carta F, Supuran CT. Bioorg Chem. 2019,89:103033. Link to Journal  |
| 153 | "Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays." Schlomann U, Dorzweiler K, Nuti E, Tuccinardi T, Rossello A, Bartsch JW. Biol Chem. 2019,400(6):801-810. Link to Journal |
| 152 | "Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines." Krasavin M, Shetnev A, Baykov S, Kalinin S, Nocentini A, Sharoyko V, Poli G, Tuccinardi T, Korsakov M, Tennikova TB, Supuran CT. Eur J Med Chem. 2019,168:301-314. Link to Journal  |
| 151 | "First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent." Lapillo M, Salis B, Palazzolo S, Poli G, Granchi C, Minutolo F, Rotondo R, Caligiuri I, Canzonieri V, Tuccinardi T, Rizzolio F. ACS Med Chem Lett. 2019,10(4):475-480. Link to Journal  |
| 150 | "The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel." De Logu F, Li Puma S, Landini L, Tuccinardi T, Poli G, Preti D, De Siena G, Patacchini R, Tsagareli MG, Geppetti P, Nassini R. Pharmacol Res. 2019,142:127-139. Link to Journal  |
| 149 | "Novel 8-substituted coumarins that selectively inhibit human carbonic anhydrase IX and XII." Buran K, Bua S, Poli G, Önen Bayram FE, Tuccinardi T, Supuran CT. Int J Mol Sci. 2019,20(5). pii: E1208. Link to Journal  |
| 148 | "Extensive reliability evaluation of docking-based target-fishing strategies." Lapillo M, Tuccinardi T, Martinelli A, Macchia M, Giordano A, Poli G. Int J Mol Sci. 2019;20(5). pii: E1023. Link to Journal  |
| 147 | "Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor." Granchi C, Lapillo M, Glasmacher S, Bononi G, Licari C, Poli G, El Boustani M, Caligiuri I, Rizzolio F, Gertsch J, Macchia M, Minutolo F, Tuccinardi T, Chicca A. J Med Chem. 2019,62(4):1932-1958. Link to Journal  |
| 146 | "Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment." Krasavin M, Shetnev A, Sharonova T, Baykov S, Kalinin S, Nocentini A, Sharoyko V, Poli G, Tuccinardi T, Presnukhina S, Tennikova TB, Supuran CT. Eur J Med Chem. 2019,164:92-105. Link to Journal  |
| 145 | "Editorial: Peptidyl-prolyl isomerases in human pathologies." Tuccinardi T, Rizzolio F. Front Pharmacol. 2019,10:794. Link to Journal |
| 144 | "Effects of different blanching treatments on microbiological profile and quality of the mealworm (Tenebrio molitor)." Mancini S, Fratini F, Tuccinardi T, Turchi B, Nuvoloni R, Paci G. Journal of Insects as Food and Feed 2019,5 225-234. Link to Journal |
| 143 | "A guide to PIN1 function and mutations across cancers." El Boustani M, De Stefano L, Caligiuri I, Mouawad N, Granchi C, Canzonieri V, Tuccinardi T, Giordano A, Rizzolio F. Front Pharmacol. 2019,9:1477. Link to Journal |
| 142 | "Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors." Poli G, Lapillo M, Jha V, Mouawad N, Caligiuri I, Macchia M, Minutolo F, Rizzolio F, Tuccinardi T, Granchi C. J Enzyme Inhib Med Chem. 2019,34(1):589-596. Link to Journal |
| 141 | "Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)." Cuffaro D, Nuti E, Gifford V, Ito N, Camodeca C, Tuccinardi T, Nencetti S, Orlandini E, Itoh Y, Rossello A. Bioorg Med Chem. 2019,27(1):196-207. Link to Journal  |
| 140 | "The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies." El Hassouni B, Granchi C, Vallés-Martí A, Supadmanaba IGP, Bononi G, Tuccinardi T, Funel N4, Jimenez CR, Peters GJ, Giovannetti E, Minutolo F. Semin Cancer Biol. 2019 . pii: S1044-579X(19)30180-4. Link to Journal |
| 139 | "Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system." Gado F1, Arena C, Fauci C, Reynoso-Moreno I, Bertini S, Digiacomo M, Meini S, Poli G, Macchia M, Tuccinardi T, Gertsch J, Chicca A, Manera C. Bioorg Chem. 2019 ,17:103353. Link to Journal  |
| 138 | "New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents." Chiarelli LR, Mori M, Beretta G, Gelain A, Pini E, Sammartino JC, Stelitano G, Barlocco D, Costantino L, Lapillo M, Poli G, Caligiuri I, Rizzolio F, Bellinzoni M, Tuccinardi T, Villa S, Meneghetti F. J Enzyme Inhib Med Chem. 2019 ,34(1):823-828. Link to Journal  |
| 137 | "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5." Mangoni AA, Eynde JJV, Jampilek J, Hadjipavlou-Litina D, Liu H, Reynisson J, Sousa ME, Gomes PAC, Prokai-Tatrai K, Tuccinardi T, Sabatier JM, Luque FJ, Rautio J, Karaman R, Vasconcelos MH, Gemma S, Galdiero S, Hulme C, Collina S, Gütschow M, Kokotos G, Siciliano C, Capasso R, Agrofoglio LA, Ragno R, Muñoz-Torrero D. Molecules. 2019,24(13). pii: E2415. Link to Journal  |
| 136 | "Anticancer activity of euplotin C, isolated from the marine ciliate euplotes crassus, against human melanoma cells" Carpi S, Polini B, Poli G, Alcantara Barata G, Fogli S, Romanini A, Tuccinardi T, Guella G, Frontini FP, Nieri P, Di Giuseppe G. Mar Drugs. 2018,16(5). pii: E166. Link to Journal  |
| 135 | "Identification of Lactate Dehydrogenase 5 Inhibitors using Pharmacophore- Driven Consensus Docking." Poli G, Scarpino A, Aissaoui M, Granchi C, Minutolo F, Martinelli A, Tuccinardi T. Current Bioactive Compounds 2018, 14:197-204. Link to Journal  |
| 134 | "New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)." De Leo M, Huallpa CG, Alvarado B, Granchi C, Poli G, De Tommasi N, Braca A. Fitoterapia 2018, 130:251-258. Link to Journal  |
| 133 | "Conformational Sampling of Small Molecules With iCon: Performance Assessment in Comparison With OMEGA." Poli G, Seidel T, Langer T. Front Chem. 2018, 6:229. Link to Journal |
| 132 | "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4." Mangoni AA, Guillou C, Vanden Eynde JJ, Hulme C, Jampilek J, Li W, Prokai-Tatrai K, Rautio J, Collina S, Tuccinardi T, Sousa ME, Sabatier JM, Galdiero S, Karaman R, Kokotos G, Torri G, Luque FJ, Vasconcelos MH, Hadjipavlou-Litina D, Siciliano C, Gütschow M, Ragno R, Gomes PAC, Agrofoglio LA, Muñoz-Torrero D. Molecules. 2018, 24(1). pii: E130. Link to Journal |
| 131 | "Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors." Bononi G, Granchi C, Lapillo M, Giannotti M, Nieri D, Fortunato S, Boustani ME, Caligiuri I, Poli G, Carlson KE, Kim SH, Macchia M, Martinelli A, Rizzolio F, Chicca A, Katzenellenbogen JA, Minutolo F, Tuccinardi T. Eur J Med Chem. 2018, 157:817-836. Link to Journal  |
| 130 | "Rational Development of MAGL Inhibitors." Granchi C, Rizzolio F, Caligiuri I, Macchia M, Martinelli A, Minutolo F, Tuccinardi T. Methods Mol Biol. 2018, 1824:335-346. Link to Journal |
| 129 | "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3." Mangoni AA, Tuccinardi T, Collina S, Vanden Eynde JJ, Muñoz-Torrero D, Karaman R, Siciliano C, de Sousa ME, Prokai-Tatrai K, Rautio J, Guillou C, Gütschow M, Galdiero S, Liu H, Agrofoglio LA, Sabatier JM, Hulme C, Kokotos G, You Q, Gomes PAC. Molecules. 2018, 23(7). pii: E1596. Link to Journal |
| 128 | "Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents." Chiarelli LR, Mori M, Barlocco D, Beretta G, Gelain A, Pini E, Porcino M, Mori G, Stelitano G, Costantino L, Lapillo M, Bonanni D, Poli G, Tuccinardi T, Villa S, Meneghetti F. Eur J Med Chem. 2018, 155:754-763. Link to Journal  |
| 127 | "Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors." Poli G, Jha V, Martinelli A, Supuran CT, Tuccinardi T. Int J Mol Sci. 2018, 19(7). pii: E1851. Link to Journal |
| 126 | "New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies." Pini E, Poli G, Tuccinardi T, Chiarelli LR, Mori M, Gelain A, Costantino L, Villa S, Meneghetti F, Barlocco D. Molecules. 2018, 23(7). pii: E1506. Link to Journal  |
| 125 | "Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system." Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C. Eur J Med Chem. 2018, 154:155-171. Link to Journal  |
| 124 | "Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells." Carpi S, Polini B, Poli G, Alcantara Barata G, Fogli S, Romanini A, Tuccinardi T, Guella G, Frontini FP, Nieri P, Di Giuseppe G. Mar Drugs. 2018, 16(5). pii: E166. Link to Journal |
| 123 | "Design, Synthesis, and Evaluation of GLUT Inhibitors." Granchi C, Tuccinardi T, Minutolo F. Methods Mol Biol. 2018, 1713:93-108. Link to Journal |
| 122 | "Identification of Lactate Dehydrogenase 5 Inhibitors using Pharmacophore- Driven Consensus Docking." Poli G, Scarpino A, Aissaoui M, Granchi C, Minutolo F, Martinelli, Tuccinardi T. Curr Bioact Comp. 2018, 14:197-204. Link to Journal |
| 121 | "Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer." Spena CR, De Stefano L, Palazzolo S, Salis B, Granchi C, Minutolo F, Tuccinardi T, Fratamico R, Crotti S, D'Aronco S, Agostini M, Corona G, Caligiuri I, Canzonieri V, Rizzolio F. J Control Release. 2018, 281:1-10. Link to Journal  |
| 120 | "Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors." Poli G, Lapillo M, Granchi C, Caciolla J, Mouawad N, Caligiuri I, Rizzolio F, Langer T, Minutolo F, Tuccinardi T. J Enzyme Inhib Med Chem. 2018, 33(1):956-961. Link to Journal |
| 119 | "Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors." Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T. J Med Chem. 2018, 61(3):1340-1354. Link to Journal  |
| 118 | "Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms." Krasavin M, Shetnev A, Sharonova T, Baykov S, Tuccinardi T, Kalinin S, Angeli A, Supuran CT. Bioorg Chem. 2018, 76:88-97. Link to Journal  |
| 117 | "Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors." Poli G, Granchi C, Aissaoui M, Minutolo F, Tuccinardi T. Molecules. 2017, 22(12):2217. Link to Journal |
| 116 | "A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017)." Granchi C, Caligiuri I, Minutolo F, Rizzolio F, Tuccinardi T. Expert Opin Ther Pat. 2017, 27(12):1341-1351. Link to Journal |
| 115 | "Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors." Granchi C, Caligiuri I, Bertelli E, Poli G, Rizzolio F, Macchia M, Martinelli A, Minutolo F, Tuccinardi T. J Enzyme Inhib Med Chem. 2017, 32(1):1240-1252. Link to Journal |
| 114 | "Lucky switcheroo: dramatic potency and selectivity improvement of imidazoline inhibitors of human carbonic anhydrase VII." Kalinin S, Kopylov S, Tuccinardi T, Sapegin A, Darin D, Angeli A, Supuran CT, Krasavin M. ACS Med Chem Lett. 2017, 8(10):1105-1109. Link to Journal  |
| 113 | "Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases." Krasavin M, Korsakov M, Ronzhina O, Tuccinardi T, Kalinin S, Tanç M, Supuran CT. J Enzyme Inhib Med Chem. 2017, 32(1):920-934. Link to Journal |
| 112 | "Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase." De Leo M, Peruzzi L, Granchi C, Tuccinardi T, Minutolo F, De Tommasi N, Braca A. J Nat Prod. 2017, 80(7):2077-2087. Link to Journal  |
| 111 | "Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer." Granchi C, Fortunato S, Meini S, Rizzolio F, Caligiuri I, Tuccinardi T, Lee HY, Hergenrother PJ, Minutolo F. J Agric Food Chem. 2017, 65(28):5639-5649. Link to Journal  |
| 110 | "Bifunctional Inhibitors as a new tool to reduce cancer cell invasion by impairing MMP-9 homodimerization." Nuti E, Rosalia L, Cuffaro D, Camodeca C, Giacomelli C, Da Pozzo E, Tuccinardi T, Costa C, Antoni C, Vera L, Ciccone L, Orlandini E, Nencetti E, Dive V, Martini C, Stura EA, Rossello A. ACS Med Chem Lett. 2017, 8(3):293-298. Link to Journal  |
| 109 | "Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds." Krasavin M, Korsakov M, Zvonaryova Z, Semyonychev E, Tuccinardi T, Kalinin S, Tanç M, Supuran CT. Bioorg. Med. Chem. 2017, 25(6):1914-1925. Link to Journal  |
| 108 | "Antibacterial and Hypoglycemic Diterpenoids from Salvia chamaedryoides." Bisio A, De Mieri M, Milella L, Schito AM, Parricchi A, Russo D, Alfei S, Lapillo M, Tuccinardi T, Hamburger M, De Tommasi N. J. Nat. Prod. 2017, 80(2):503-514. Link to Journal  |
| 107 | "Immunomodulatory Properties of 1,2-Dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide Derivative VL15." Malfitano AM, Laezza C, Bertini S, Marasco D, Tuccinardi T, Bifulco M, Manera C. Biochimie. 2017, 135:173-180. Link to Journal |
| 106 | "Bottom-Up Synthesis of Carbon Nanoparticles with Higher Doxorubicin Efficacy." Bayda S, Hadla M, Palazzolo S, Kumar V, Caligiuri I, Ambrosi E, Pontoglio E, Agostini M, Tuccinardi T, Benedetti A, Riello P, Canzonieri V, Corona G, Toffoli G, Rizzolio F. J Contr. Rel. 2017, 248:144-152. Link to Journal  |
| 105 | "Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies." Poli G, Martinelli Tuccinardi T. J Enzyme Inhib Med Chem. 2016, 31(sup2):167-173. Link to Journal |
| 104 | "Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors." Granchi C, Rizzolio F, Palazzolo S, Carmignani S, Macchia M, Saccomanni G, Manera C, Martinelli A, Minutolo F, Tuccinardi T. J Med Chem. 2016, 59(22):10299-10314. Link to Journal  |
| 103 | "Drug affinity responsive target stability (DARTS) identifies laurifolioside as a new clathrin heavy chain modulator." Dal Piaz F, Saltos MBV, Franceschelli S, Forte G, Marzocco S, Tuccinardi T, Poli G, Ebrahimi SN, Hamburger M, De Tommasi N, Braca A. J Nat Prod. 2016, 79(10):2681-2692. Link to Journal  |
| 102 | "Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation." Rotondo R, Moschini R, Renzone G, Tuccinardi T, Balestri F, Cappiello M, Scaloni A, Mura U, Del-Corso A. Free Radic Biol Med. 2016, 99:323-332. Link to Journal  |
| 101 | "α-Glucosidase and α-Amylase Inhibitors from Arcytophyllum thymifolium." Milella L, Milazzo S, De Leo M, Vera Saltos M, Faraone I, Tuccinardi T, Lapillo M, De Tommasi N, Braca A. J Nat Prod. 2016, 79(8):2104-12. Link to Journal  |
| 100 | "Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds." Petrou A, Geronikaki A, Terzi E, Ozensoy Guler O, Tuccinardi T, Supuran CT. J Enzyme Inhib Med Chem. 2016, 31(6):1306-1311. Link to Journal |
| 99 | "A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach." Tuccinardi T, Poli G, Corchia I, Granchi C, Lapillo M, Macchia M, Minutolo F, Ortore G, Martinelli A. Molecular Inf. 2016, 35(8-9):434-439. Link to Journal  |
| 98 | "Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach." Poli G, Gelain A, Porta F, Asai A, Martinelli A, Tuccinardi T. J Enzyme Inhib Med Chem. 2016, 31(6):1011-1017. Link to Journal |
| 97 | "Cyclic Ketoximes as Estrogen Receptor β Selective Agonists." Granchi C, Lapillo M, Spena CR, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. ChemMedChem. 2016, 11(16):1752-61. Link to Journal  |
| 96 | "Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII." Kumar S, Ceruso M, Tuccinardi T, Supuran CT, Sharma PK. Bioorg Med Chem. 2016, 24(13):2907-29013. Link to Journal  |
| 95 | "Synthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists." Tabrizi MA, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Poli G, Tuccinardi T, Ravani A, Vincenzi F, Borea PA, Varani K. Eur J Med Chem. 2016, 113:11-27. Link to Journal  |
| 94 | "Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin’s lymphoma cell models." Camodeca C, Nuti E, Tepshi L, Boero S, Tuccinardi T, Stura EA, Poggi A, Zocchi MR, Rossello A. Eur J Med Chem. 2016, 111:193-201. Link to Journal  |
| 93 | "4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors." Granchi C, Rizzolio F, Bordoni V, Caligiuri I, Manera C, Macchia M, Minutolo F, Martinelli A, Giordano A, Tuccinardi T. J Enzyme Inhib Med Chem. 2016 31(1):137-146. Link to Journal |
| 92 | "Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells." Granchi C, Qian Y, Yeon Lee H, Paterni I, Pasero C, Iegre J, Carlson KE, Tuccinardi T, Chen X, Katzenellenbogen JA, Hergenrother PJ, Minutolo FM. ChemMedChem. 2015, 10(11):1892-1900. Link to Journal  |
| 91 | "N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in vivo Antiangiogenic Activity." Nuti E, Cantelmo AR, Gallo C, Bruno A, Bassani B, Camodeca C, Tuccinardi T, Vera L, Orlandini E, Nencetti S, Stura EA, Martinelli A, Dive V, Albini A, Rossello A. J Med Chem. 2015, 58(18):7224-7240. Link to Journal ![](http://www.mmvsl.it/wp/wp-content/uploads/2015/08/91.gif") |
| 90 | Probing the ‘bipolar’ nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms." Krasavin M, Korsakov M, Dorogov M, Tuccinardi T, Dedeoglu N, Supuran CT. Eur J Med Chem. 2015, 101:334-347. Link to Journal ![](http://www.mmvsl.it/wp/wp-content/uploads/2015/06/90.jpg") |
| 89 | "Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands." Tuccinardi T, Poli G, dell’Agnello M, Granchi C, Minutolo F, Martinelli A. J Enzyme Inhib Med Chem. 2015, 30(4):662-670. Link to Journal |
| 88 | "The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives." Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. Br J Pharmacol. 2015, 172(13):3397-3411. Link to Journal |
| 87 | "Studies on the ATP binding site of Fyn kinase for the identification of new inhibitors and their evaluation as potential agents against tauopathies and tumors." Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M. J Med Chem. 2015 58(11):4590-4609. Link to Journal ![](http://www.mmvsl.it/wp/wp-content/uploads/2015/04/86.jpg") |
| 86 | "Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)." Tabrizi MA, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Romagnoli R, Martinelli A, Tuccinardi T. Eur J Med Chem. 2015, 97:289-305. Link to Journal ![](http://www.mmvsl.it/wp/wp-content/uploads/2015/05/87.jpg") |
| 85 | "Phenylpropanoids and Flavonoids from Phlomis kurdica as Inhibitors of Human Lactate Dehydrogenase." Bader A, Tuccinardi T, Granchi C, Martinelli A, Macchia M, Minutolo F, De Tommasi N, Braca A. Phytochem. 2015, 116:262-268. Link to Journal  |
| 84 | "Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors" Granchi C, Capecchi A, Del Frate G, Martinelli A, Macchia M, Minutolo F, Tuccinardi T. Molecules. 2015, 20(5):8772-8790. Link to Journal  |
| 83 | "Application of a FLAP-Consensus Docking Mixed Strategy for the Identification of New FAAH Inhibitors" Poli G, Giuntini N, Martinelli A, Tuccinardi T. J Chem Inf Model. 2015, 55(3):667-675. Link to Journal  |
| 82 | "Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents." Di BussoloV, Calvaresi EC, Granchi C, Del Bino L, Frau I, Dasso Lang MC, Tuccinardi T, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. RSC Adv. 2015, 5(26):19944-19954. Link to Journal  |
| 81 | "Highly selective salicylketoxime-based estrogen receptor beta agonists display antiproliferative activities in a glioma model." Paterni I, Bertini S, Granchi C, Tuccinardi T, Macchia M, Martinelli A, Caligiuri I, Toffoli G, Rizzolio F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Minutolo F. J Med Chem. 2015, 58(3):1184–1194. Link to Journal  |
| 80 | "Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins." Enyedy EA, Dömötör O, Bali K, Hetényi A, Tuccinardi T, Keppler BK. J Biol Inorg Chem. 2015, 20(1):77-88 Link to Journal  |
| 79 | "Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1." Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone I, Minocci D, De Logu F, Tuccinardi T, Di Tommaso M, Susini T, Moneti G, Pieraccini G, Geppetti P, Nassini R. Nature Communications 2014 , 5:5736. Link to Journal |
| 78 | "Extensive Consensus Docking Evaluation for Ligand Pose Prediction and Virtual Screening Studies." Tuccinardi T, Poli G, Romboli V, Giordano A, Martinelli A. J Chem Inf Model. 2014, 54(10):2980-2986. Link to Journal  |
| 77 | "Computational approaches for the identification and optimization of SRC family kinases inhibitors." Poli G, Martinelli A, Tuccinardi T. Curr Med Chem. 2014, 21(28):3281-3293. Link to Journal |
| 76 | "Identification and characterization of a new reversible MAGL inhibitor." Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. Bioorg Med Chem. 2014, 22(13):3285-3291. Link to Journal  |
| 75 | "Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor." Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC. J Am Chem Soc. 2014, 136(17):6355-6361. Link to Journal  |
| 74 | "Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin." Digilio G, Tuccinardi T, Casalini F, Cassino C, Dias DM, Geraldes CF, Catanzaro V, Maiocchi A, Rossello A. Eur J Med Chem. 2014 2014, 79:13-23 Link to Journal  |
| 73 | "Interaction of anticancer reduced Schiff base coumarin derivatives with human serum albumin investigated by fluorescence quenching and molecular modeling." Dömötör O, Tuccinardi T, Karcz D, Walsh M, Creaven BS, Enyedy EA. Bioorg Chem. 2014, 52:16-23. Link to Journal  |
| 72 | "Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells." Tuccinardi T, Granchi C, Iegre J, Paterni I, Bertini S, Macchia M, Martinelli A, Qian Y, Chen X, Minutolo F. Bioorg Med Chem Lett. 2013, 23(24):6923-7. Link to Journal  |
| 71 | "Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor." Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens RW 3rd, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ. Chembiochem. 2013, 14(17):2263-7. Link to Journal  |
| 70 | "Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives." Malfitano AM, Laezza C, Saccomanni G, Tuccinardi T, Manera C, Martinelli A, Ciaglia E, Pisanti S, Vitale M, Gazzerro P, Bifulco M. J Neuroimmune Pharmacol. 2013, 8(5):1077-86. Link to Journal |
| 69 | "Identification of new FYN kinase inhibitors using a FLAP-based approach." Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. J Chem Inf Model. 2013, 53(10):2538-47. Link to Journal  |
| 68 | "Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds." Granchi C, Calvaresi EC, Tuccinardi T, Paterni I, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. Org Biomol Chem. 2013 ,11(38):6588-96. Link to Journal  |
| 67 | "Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists." Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, Moorman AR, Romagnoli R, Preti D, Baraldi S, Ruggiero E, Tintori C, Tuccinardi T, Vincenzi F, Borea PA, Varani K. J Med Chem. 2013, 56(11):4482-96. Link to Journal  |
| 66 | "Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis." Malfitano AM, Laezza C, D'Alessandro A, Procaccini C, Saccomanni G, Tuccinardi T, Manera C, Macchia M, Matarese G, Gazzerro P, Bifulco M. PLoS One. 2013, 8(5):e62511. Link to the Journal  |
| 65 | "Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors." Tuccinardi T, Bertini S, Granchi C, Ortore G, Macchia M, Minutolo F, Martinelli A, Supuran CT. Bioorg Med Chem. 2013, 21(6):1511-5. Link to the Journal  |
| 64 | "Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder." Wong CH, Richardson SL, Ho YJ, Lucas AM, Tuccinardi T, Baranger AM, Zimmerman SC. Chembiochem. 2012, 13(17):2505-9. Link to Journal  |
| 63 | "Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold." Manera C, Saccomanni G, Malfitano AM, Bertini S, Castelli F, Laezza C, Ligresti A, Lucchesi V, Tuccinardi T, Rizzolio F, Bifulco M, Di Marzo V, Giordano A, Macchia M, Martinelli A. Eur J Med Chem. 2012, 52:284-94. Link the Journal  |
| 62 | "Computational studies on translocator protein (TSPO) and its ligands." Ortore G, Tuccinardi T, Martinelli A. Curr Top Med Chem. 2012, 12(4):352-9. Link to the Journal |
| 61 | "Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5." Granchi C, Roy S, Mottinelli M, Nardini E, Campinoti F, Tuccinardi T, Lanza M, Betti L, Giannaccini G, Lucacchini A, Martinelli A, Macchia M, Minutolo F. Bioorg Med Chem Lett. 2011, 21(24):7331-6. Link to the Journal  |
| 60 | "Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases." Marques SM, Tuccinardi T, Nuti E, Santamaria S, André V, Rossello A, Martinelli A, Santos MA. J Med Chem. 2011, 54(24):8289-98. Link to the Journal  |
| 59 | "N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation." Granchi C, Roy S, De Simone A, Salvetti I, Tuccinardi T, Martinelli A, Macchia M, Lanza M, Betti L, Giannaccini G, Lucacchini A, Giovannetti E, Sciarrillo R, Peters GJ, Minutolo F. Eur J Med Chem. 2011, 46(11):5398-407. Link to the Journal  |
| 58 | "Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies." Enyedy EA, Horváth L, Hetényi A, Tuccinardi T, Hartinger CG, Keppler BK, Kiss T. Bioorg Med Chem. 2011, 19(14):4202-10. Link to the Journal  |
| 57 | "Protein kinase homology models: recent developments and results." Tuccinardi T, Martinelli A. Curr Med Chem. 2011, 18(19):2848-53. Link to the Journal |
| 56 | "Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation." Carrasco MP, Enyedy EA, Krupenko NI, Krupenko SA, Nuti E, Tuccinardi T, Santamaria S, Rossello A, Martinelli A, Santos MA. Med Chem. 2011 , 7(4):265-74. Link to the Journal |
| 55 | "Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes." Bertini S, De Cupertinis A, Granchi C, Bargagli B, Tuccinardi T, Martinelli A, Macchia M, Gunther JR, Carlson KE, Katzenellenbogen JA, Minutolo F. Eur J Med Chem. 2011, 46(6):2453-62. Link to the Journal  |
| 54 | "Binding-interaction prediction of RNA-binding ligands." Tuccinardi T. Future Med Chem. 2011, 3(6):723-33. Link to the Journal |
| 53 | "Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity." Tuccinardi T, Zizzari AT, Brullo C, Daniele S, Musumeci F, Schenone S, Trincavelli ML, Martini C, Martinelli A, Giorgi G, Botta M. Org Biomol Chem. 2011, 9(12):4448-55. Link to the Journal  |
| 52 | "Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells." Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F. J Med Chem. 2011, 54(6):1599-612. Link to the Journal  |
| 51 | "Different binding modes of structurally diverse ligands for human D3DAR." Ortore G, Tuccinardi T, Orlandini E, Martinelli A. J Chem Inf Model. 2010, 50(12):2162-75. Link to the Journal  |
| 50 | "Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties." Bertini S, Calderone V, Carboni I, Maffei R, Martelli A, Martinelli A, Minutolo F, Rajabi M, Testai L, Tuccinardi T, Ghidoni R, Macchia M. Bioorg Med Chem. 2010, 18(18):6715-24. Link to the Journal  |
| 49 | "Protein kinases: docking and homology modeling reliability." Tuccinardi T, Botta M, Giordano A, Martinelli A. J Chem Inf Model. 2010, 50(8):1432-41. Link to the Journal  |